Sleep is essential for wellbeing and overall health. We spend up to a third of our lives asleep and the general state of “sleep health” is an important question throughout our lifespan. The CDC has estimated that 1 in 3 American Adults do not achieve the recommendation of at least 7 hours of sleep each night for adults aged 18–60 years. Inadequate sleep has been associated with an increased risk of developing chronic conditions such as cancer, obesity, diabetes, high blood pressure, heart disease, stroke, and dementia. Bryan James and Rachael Stolzenberg-Solomon host a discussion with Neil Caporaso, a Senior Investigator in the Occupational and Environmental Epidemiology Branch, in the Division of Cancer Epidemiology and Genetics at the National Cancer Institute about the epidemiology and science of sleep and health.