Drs. Justin Lessler from Johns Hopkins Bloomberg School of Public Health and Michael Mina from the Harvard School of Public Heath are back for a fourth episode to discuss the coronavirus pandemic with host Bryan James. Between our first podcast in early February 2020 and this recording, the pandemic has grown from 11 cases of COVID-19 in the US to over 1.3 million known cases and 84 thousand deaths in the US. After 2 months of shelter-in-place lockdown measures throughout most of the country, many states and cities are beginning to reopen their economies, raising concerns of a second wave of the pandemic. This discussion focuses on how to reopen the country safely; the significance of both virology and serology testing for surveillance; and some helpful advice on how to keep yourself and your family safe during the pandemic.